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Calcium Phosphate Crystals

Richard's work recently featured on the front cover of the Journal of Materials Chemistry (B). This work described how it was possible to modify the surface of calcium phosphate crystals, so that we could monitor what happens to them as they cross the cell membrane.

In-vitro Tissue-Engineered Ligament

The collagen accumulation in fibrin-based tissue-engineered ligaments can be augmented using promoters of collagen synthesis. Our current work aims to optimise collagen production in vitro using AA+P and other collagen synthesis promoters

Mechanical Stimulation of Tissue-Engineered Ligaments

Mechanical stimulation imparts critical signals that influence musculoskeletal tissue development and biomechanical properties. A bioreactor can be used to load the ligament constructs in vitro. Our current work aims to optimise a mechanical stimulation regime to augment graft properties.

Collagen production in fibrin-based ligaments

Tissue Engineering

The collagen accumulation in fibrin-based tissue-engineered ligaments can be augmented using promoters of collagen synthesis. By supplementing the ligaments with ascorbic acid and proline, we can increase collagen deposition and mechanical properties of the grafts. Our current work aims to optimise collagen production in vitro using AA+P and other collagen synthesis promoters.

Acicular Magnetite Nanoparticles via Biologically-controlled Precipitation

Biomineralisation is the ability of biological organisms to induce, control and/or inhibit the formation of a wide range of mineral forms: typically through protein-ion interaxtions. Many organisms exhibit highly specialised magnetic nanopartickes that have been replicated in vitro by coprecipitation in the prescence of recombinant protein. These acicular nanoparticles are formed when iron oxide is precipoitated in the presence of bovine serum albumin

How to contact us

The TRAILab at the University of Birmingham develops innovative solutions for the regeneration of a multitude of tissues, and works to further our understanding of biomineralisation.

We are proud to have worked with both academic and industrial contacts on complex interdisciplinary projects and are continously looking for additional collaboration partners.

General queries for the TRAILab may be sent to the addresses below, individual group member's contact details are provided.

Professor Liam Grover

Biochemical Engineering

Department of Chemical Engineering

University of Birmingham

Edgbaston

B15 2TT

E mail: TRAILab

Contact Us at TRAILab